Innate PI3K p110d Regulates Th1/Th17 Development and Microbiota-Dependent Colitis
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چکیده
منابع مشابه
Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis.
The p110δ subunit of class IA PI3K modulates signaling in innate immune cells. We previously demonstrated that mice harboring a kinase-dead p110δ subunit (p110δ(KD)) develop spontaneous colitis. Macrophages contributed to the Th1/Th17 cytokine bias in p110δ(KD) mice through increased IL-12 and IL-23 expression. In this study, we show that the enteric microbiota is required for colitis developme...
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